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Monday, March 3, 2008

The risks of flutamide include xerosis.

Finasteride is generally regarded as the least effective, but it is usually well tolerated and has minimal side effects apart from teratogenicity. However, several studies, including some randomized, double-blind studies, have demonstrated similar clinical efficacy among finasteride, flutamide, and spironolactone, though their big businessman was likely not great enough to detect a statistical quality. Other randomized studies have confirmed the combatant clinical efficacy of spironolactone.

The risks of flutamide include xerosis and hepatotoxicity at higher doses. Spironolactone can lead to electrolyte disturbances. In patients for whom these are issues of business organisation, finasteride is the best action.

Finasteride for Idiopathic Hirsutism.

There are many causes of hirsutism in women. Often these causes relate to endocrinopathies, but idiopathic hirsutism may also occur without obvious unhealthiness. For both types of hirsutism, antiandrogen therapy is often employed. For endocrinopathy-related hirsutism, discussion of the underlying condition is also important and effective.
The most commonly used and studied pharmacologic antiandrogens include cyproterone rayon (progesterone-like and antigonadotropic), spironolactone (antimineralocorticoid), flutamide (pure androgen complex body part blocker), and finasteride (5 alpha-reductase inhibitor). Cyproterone ethanoate is among the more effective, but it is not available in the United States. The 3 remaining agents offering physicians choices of varying efficacy and risk. All 3 agents are teratogenic and must be prescribed in connection with a pregnancy-prevention plan in women of reproductive age.

Medscape Medical News.

Types of FPHL include Christmastide tree, Ludwig, and William Rowan Hamilton patterns.The use of 2.5 mg of finasteride daily combined with an oral contraceptive containing drospirenone and ethinyl estradiol is associated with some transmutation in FPHL at 1 year.
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